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Signals that Govern Cell Behavior in Embryos, During Tissue Repair, and in Cancer
Philip Beachy, Stanford University
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In complex organisms such as ourselves, cells must coordinate their proliferation and differentiation to build and maintain normal tissues and structures. The Hedgehog signaling protein is one of the extracellular signals that cells use to coordinate their behavior. Hedgehog signaling has profoundly important roles in the normal processes of embryonic development and tissue regeneration, is improperly activated or lost in disease processes such as cancer or tissue degeneration.
About Philip Beachy
After completing his Ph.D. at Stanford University in 1986, Philip Beachy became a Staff Associate at the Carnegie Institution’s Department of Embryology in Baltimore, moving to the Department of Molecular Biology and Genetics at The Johns Hopkins University School of Medicine in 1988. He returned to Stanford University in 2006, and his research laboratory is at the School of Medicine in the Institute for Stem Cell Biology and Regenerative Medicine.
Beachy is the Ernest and Amelia Gallo Professor in the School of Medicine. He was elected to the National Academy of Sciences in 2002 and the American Academy of Arts and Sciences in 2003, and was an investigator of the Howard Hughes Medical Institute from 1988-2017. He received the National Academy of Sciences Prize and Medal in Molecular Biology (1998), the March of Dimes Prize in Developmental Biology (2008), the Keio Medical Science Prize (2011), and the Katharine Berkan Judd Award for Cancer Research from Sloan Kettering Institute (2016).
His recent work has focused on the role of the stem cell niche in controlling stem cell activity during normal tissue maintenance and in pathological settings such as cancer and degenerative disease. His laboratory also continues to investigate the unusual mechanisms that mediate Hedgehog protein signaling.
Audience: Public
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